Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-a
Human,Mouse,Rat,Rabbit(predicted: Cow)
WB,IHC-P,IHC-F,IF
Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.